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. Author manuscript; available in PMC: 2018 Dec 15.
Published in final edited form as: Biol Psychiatry. 2017 May 22;82(12):914–923. doi: 10.1016/j.biopsych.2017.05.013

Figure 4.

Figure 4

Effects of chronic stress and inhibiting neurogenesis on depressive-like behavior. A. Unpredictable restraint stress decreases weight, while genotype has no effect in food restricted rats (3-way ANOVA, genotype x day interaction: F(27,1134) = 0.52, p = .98; stress x day interaction: F(27,1134) = 100.30, p < .0001; stress slope comparison: F(1,1284) = 66.39, p < .0001, * p < .05 for slope compared to controls B. Chronic stress increases latency to feed in the novelty-suppressed feeding test, but inhibiting neurogenesis does not have a significant effect (2-way ANOVA, main effect of stress: F(1,40) = 9.89, p = .003; main effect of genotype: F(1,40) = 3.26, p = .08; stress x genotype interaction: F(1,40) = 0.01, p = .94). C,D. Chronic stress increases sucrose consumption (2-way ANOVA, main effect of stress F(1,31) = 11.69, p = .002), but does not affect water consumption (2-way ANOVA, main effect of stress: F(1,31) = 1.30, p = .26). For all graphs, WT control = white, TK control = blue, WT stress = yellow, TK stress = green. N = 9–10 for all graphs; all graphs represent means+SEM.