Table 3. Sensitivity and Specificity of Methylated Stool DNA among Subgroups.
| SFRP2 | TFPI2 | NDRG4 | BMP3 | Combinationa | |
|---|---|---|---|---|---|
| Colorectal cancer (n=35) | |||||
| No. of positive results | 21 | 11 | 24 | 14 | 33 |
| Sensitivity (%) | 60.0 | 31.4 | 68.8 | 40.0 | 94.3 |
| 95% CI | 43.0–77.0 | 15.0–48.0 | 52.0–85.0 | 23.0–57.0 | 86.2–100.0 |
| Advanced adenoma (n=36) | |||||
| No. of positive results | 10 | 10 | 10 | 12 | 26 |
| Sensitivity (%) | 27.8 | 27.8 | 27.8 | 33.3 | 72.2 |
| 95% CI | 12.4–43.2 | 12.4–43.2 | 12.4–43.2 | 17.2–49.5 | 43.0–77.0 |
| Normal (n=40) | |||||
| No. of positive results | 5 | 4 | 8 | 6 | 18 |
| Specificity (%) | 87.5 | 90.0 | 80.0 | 85.0 | 55.0 |
| 95% CI | 76.8–98.2 | 80.3–99.7 | 67.0–92.9 | 73.4–96.5 | 38.9–71.1 |
aHypermethylation of 1 of the 4 promoters (SFRP2, TFPI2, NDRG4, and BMP3).
SFRP2, secreted frizzled-related protein 2; TFPI2, tissue factor pathway inhibitor 2; NDRG4, N-myc downstream-regulated gene 4; BMP3, bone morphogenetic protein 3.