Table 6.
Frequency of adverse drug reactions in relation to prescriptions in the three largest diagnostic subgroups in adults and children, respectively
| Adults (≥ 18 years) | Children (0–17 years) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Circulatory (I00–I99)a | Musculoskeletal (M00–M99)a | Respiratory (ICD-10 J00–J99)a | Respiratory (ICD-10 J00–J99)a | Infectious (A00–B99)a | Symptoms, signs, findings (R00–R99)a | |||||||
| AMPs | Non-AMPs | AMPs | Non-AMPs | AMPs | Non-AMPs | AMPs | Non-AMPs | AMPs | Non-AMPs | AMPs | Non-AMPs | |
| Patients of prescriber physicians | ||||||||||||
| ADRs, Grades I–IV | 8 | 18 | 11 | 10 | 9 | 13 | 24 | 154 | 3 | 82 | 5 | 22 |
| Prescriptions | 3614 | 4665 | 4145 | 2995 | 3922 | 2784 | 18,261 | 40,217 | 6690 | 19,926 | 6162 | 10,759 |
| ADRs/prescriptions (%) | 0.221 | 0.386 | 0.265 | 0.334 | 0.229 | 0.467 | 0.131 | 0.383 | 0.045 | 0.412 | 0.081 | 0.204 |
| Patients with ADR | 7 | 17 | 11 | 10 | 8 | 12 | 23 | 145 | 3 | 80 | 5 | 22 |
| Patients with prescriptions | 878 | 678 | 1013 | 716 | 1670 | 1159 | 6429 | 6641 | 3732 | 5711 | 3463 | 4384 |
| Patients with ADR/with prescriptions (%) | 0.80 | 2.51 | 1.09 | 1.40 | 0.48 | 1.04 | 0.36 | 2.18 | 0.08 | 1.40 | 0.14 | 0.50 |
| Patients of all physicians | ||||||||||||
| ADRs, Grades III–IV only | 2 | 7 | 1 | 7 | 2 | 7 | 2 | 14 | 0 | 6 | 0 | 2 |
| Prescriptions | 11,904 | 25,408 | 13,404 | 17,250 | 13,314 | 14,681 | 61,127 | 74,714 | 18,689 | 31,078 | 18,485 | 24,343 |
| ADRs/prescriptions (%) | 0.017 | 0.028 | 0.007 | 0.041 | 0.015 | 0.048 | 0.003 | 0.019 | 0.000 | 0.019 | 0.000 | 0.008 |
| Patients with ADR | 2 | 7 | 1 | 7 | 2 | 7 | 2 | 14 | 0 | 6 | 0 | 2 |
| Patients with prescriptions | 3613 | 3490 | 4004 | 3662 | 5795 | 4626 | 19,414 | 17,187 | 10,082 | 11,928 | 9906 | 10,334 |
| Patients with ADR/with prescriptions (%) | 0.06 | 0.20 | 0.02 | 0.19 | 0.03 | 0.15 | 0.01 | 0.08 | 0.000 | 0.05 | 0.000 | 0.02 |
ADRs adverse drug reactions, AMPs anthroposophic medicinal products, non-AMPs all other medicinal products
aInternational Classification of Diseases (ICD) diagnosis chapter