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Proposed mechanism of NLRP3 activation by β-glucan and CpG in circulating human B-lymphocytes. β-glucan and CpG activate NLRP3 in peripheral B-lymphocytes. While β-glucan activated B-lymphocytes secrete IL-1β via NLRP3 activation (1), CpG does not induce IL-1β but IgM (2). CpG-induced IgM via NLRP3 is mammalian target of rapamycin (mTOR)-dependent but not β-glucan-mediated IL-1β secretion.
