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. 2017 Nov 9;11:102. doi: 10.3389/fnana.2017.00102

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Copyright © 2017 Popovitchenko and Rasin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Post-transcriptional processing steps in the neocortex. At the top of the figure, the progression of mRNA post-transcriptional processing is shown. Transcription begins in the nucleus (Nuc) from chromosomes producing pre-mRNA. Pre-mRNA is processed in the nucleus where the Exon-Junction Complex (EJC) will label the mRNA after splicing and help with nucleo-cytoplasmic transport. Once the transcript is moving to and throughout the cytoplasm (Cyt), stability of the mRNA becomes paramount. Here, transcripts will be stabilized (top transcript) or degraded (lower transcript). Then, transcripts will be localized to their final compartments of translation, in this case the synapse (Syn).