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. 2017 Nov 9;11:85. doi: 10.3389/fncir.2017.00085

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Copyright © 2017 Takei, Yamamoto, Bae, Shirakawa and Kobayashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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JNJ5207852 (10 μM), an H₃ receptor antagonist, blocks RAMH-induced suppression of uIPSCs in FS/non-FS→Pyr connections. (A) A scheme of a FS→Pyr connection with suprathreshold voltage responses of FS and Pyr cells in response to depolarizing current pulse injection. (B) uIPSC recordings from the pyramidal cell in response to an injection of five short train pulses to the FS (2 ms, +80 mV, 20 Hz; upper traces) shown in (A) (Vh = –70 mV). Eleven consecutive traces (gray) and their average traces (black) are shown. RAMH (10 μM) had little effect on the uIPSC amplitude under application of JNJ5207852. (C) Time course of the uIPSC amplitude. The periods of JNJ5207852 and RAMH application are shown on the top of the graph. (D) The slight effect of RAMH on the uEPSC (n = 8) and uIPSC amplitude under application of JNJ5207852 (n = 13).