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. 2017 Nov 9;11:85. doi: 10.3389/fncir.2017.00085

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Copyright © 2017 Takei, Yamamoto, Bae, Shirakawa and Kobayashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of 10 μM RAMH on miniature IPSCs (mIPSCs) recorded from the IC layer V pyramidal cells under the application of 1 μM TTX, 50 μM D-(-)-2-amino-5-phosphonopentanoic acid (D-APV), and 20 μM 6,7-dinitroquinoxaline-2,3-dione (DNQX). (A,B) An example of mIPSCs recorded before (A) and during the application of RAMH (B). The holding potential was set at 0 mV. Bottom panels (a–c) are time-expanded views of the regions indicated with bars under the top trace. (C) Cumulative probability plots of the interevent interval (left) and the amplitude of the mIPSCs (right) shown in (A,B). Note that RAMH (thick black lines) increased the interevent interval of mIPSCs without changing their amplitude. (D) Mean interevent interval (left) and the amplitude of mIPSCs (right) in controls and during RAMH application. RAMH increased the mIPSC interevent interval (^∗P < 0.05, paired t-test).