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. 2017 Nov 13;8:1457. doi: 10.1038/s41467-017-01388-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Inhibition of the PLCγ pathway impairs IL-7-mediated metabolism of B cell progenitors. a, b BM⁻derived Rag1-deficient B cell progenitors were cultured with IL-7 plus DMSO, CP690550, U73122, or edelfosine. c, d B220⁺IgM⁻IL-7R⁺ B cell progenitors were sorted from wild-type mice and cultured without IL-7 (medium) or with IL-7 plus DMSO, CP690550, U73122, or edelfosine. After measuring basal OCR (a, c) and ECAR (b, d), oligomycin A (A), FCCP (B), and antimycin (C) were sequentially added. Error bars show ± SEM. Data shown are obtained from 5 (a, b) and 3 (c, d) independent experimentsED: On your figures please ensure all instances of PLCy refer to proteins, and <Emphasis Type="Italic">Plcg</Emphasis> is used to refer to the gene.