FIGURE 4.

(A) VOA and BA reduced diarrhea after 5-FU induced intestinal mucositis. Stool from the 5-FU group and other treatment groups. (B) Reduced intestinal damage after VOA and BA treatment. Photomicrographs (10×) of the jejunums from the control, model, and treatment groups (n = 3). 5-FU shortened villi, deepened crypts, and increased inflammatory cell infiltration. VOA and BA reduced this side effect. (C) Reversion of 5-FU-induced intestinal morphometric changes by VOA and BA in rats, n = 3. Segments of jejunum retrieved to measure villus height, crypt depth and the villus:crypt ratios. ^∗Significant difference compared to the controls. Values are means ± SD. ^# Significant difference compared to the model and controls. ^∗p < 0.05, ^#p < 0.05, and ^##p < 0.01.