Table 2.
Analysis of integration sites as genome safe harbors.
| Position and Criteria for GSH | BF5 site | BF4 site | BF10 site |
|---|---|---|---|
| Chromosome | 5 | 4 | 10 |
| Gene bank accession | NW-001495037 | NW-003103903 | NW-001492885 |
| Context | intergenic | intergenic | intergenic |
| Distance to up-stream gene | RASSF3 90 kb | GLI3 0.2 kb | FLRT2 43 kb |
| Distance to down-stream gene | TBK1 100 kb | INHBA 186 kb | LOC1001 900 kb |
| At least 50 kb from 5′ end of any gene | ✓ | — | — |
| At least 300 kb from cancer related genes | ✓ | ✓ | ✓ |
| At least 300 kb from any microRNA | ✓ | ✓ | ✓ |
| Outside of gene transcription unit | ✓ | ✓ | ✓ |
| Outside of ultra-conserved regions | ✓ | ✓ | ✓ |