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. 2017 Nov 13;7:15400. doi: 10.1038/s41598-017-15500-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(I) Biodistribution of compound-6 and AmpB: Concentration of compound-6 and AmpB in each organ was expressed in µg/g. (II) Fungal load: Fungal load was estimated in PDA plates. Absence of yeast colonies were observed in effective dose treatment group. (III) Gross observation of systemic organs of various study groups: Organ damage was observed in disease and low dose treated groups. Liver abnormality was recorded in AmpB treated. The organs were normal in effective dose treated group and were similar in appearance to that of control. Bar represents mean and SD for triplicates. *Represents p ≤ 0.05; comparison by One-way and two-way ANOVA followed by Tukey’s multiple comparisons test (Supplementary Table S4) and graphs were obtained using GraphPad Prism software.