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. 2017 Nov 13;8:1464. doi: 10.1038/s41467-017-01444-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — APOE4 is associated with increased expression of small molecules related to energy metabolism. Targeted metabolite profiling was performed on small-molecule metabolites extracted from the EC and PVC of aged APOE mice (14–15 months old; 8 APOE3/3, 9 APOE3/4, and 7 APOE4/4 males). a Scatter dot plots depicting metabolite abundance in the EC for five energy-related metabolites found to be upregulated (Mann–Whitney; malate, p = 0.037; citrate/isocitrate, p = 0.028; ATP, p = 0.049; fructose-6-phosphate, p = 0.011; carnitine, p = 0.021) in APOE4 EC (black lines represent mean values and SEM). b Schematic of the energy metabolism-related metabolites found to be dysregulation in APOE4 EC. (*p ≤ 0.05)