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. 2017 Nov 13;7:15428. doi: 10.1038/s41598-017-15832-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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5-HT, 5-Htr1a specific agonist and 5-Htr1b specific agonist down-regulates AR expression in human prostatic cells. (a) Western blot analysis of AR expression in the three cell lines after 5-HT, 8-OH-DPAT and anpirtoline treatment. (b) Quantification of AR in BPH-1 and (c) WPMY-1 cells after 5-HT treatment in medium conditions without or with Testosterone supplementation. (d) Quantification of AR protein levels in BPH-1 and (e) WPMY-1 cells after 8-OH-DPAT treatment in medium conditions without or with Testosterone supplementation. (f) Quantification of AR protein levels in BPH-1 and (g) WPMY-1 cells after Anpirtoline treatment in medium conditions without or with Testosterone supplementation. The data are expressed relative to control condition (0 µM 5-HT without testosterone supplementation) and were reproduced in at least three independent experiments. Full, uncropped gel images are shown. Error bars indicate s.e.m. n.s. non-significant; *P < 0.05; **P < 0.01; ***P < 0.001; two-way ANOVA and Bonferroni post hoc test. AR, androgen receptor; 5-HT, serotonin.