Table 2.
Genetic variants distribution in different profiles of propofol metabolism rate.
| Gene | Change | Genotype | Intermediate metaboliser | Rapid metaboliser | Poor metaboliser | Statistical significance (P-value) |
|---|---|---|---|---|---|---|
| CYP2C9 | c.1075 A > C p.I359L | AA | 40 | 21 | 18 | 0.747 |
| AC | 3 | 3 | 2 | |||
| CC | 0 | 0 | 0 | |||
| c.835 C > A p.P279T | CC | 42 | 24 | 20 | 0.595 | |
| CA | 1 | 0 | 0 | |||
| AA | 0 | 0 | 0 | |||
| c.430 C > T p.R144C | CC | 28 | 18 | 12 | 0.549 | |
| CT | 15 | 6 | 8 | |||
| TT | 0 | 0 | 0 | |||
| −1188T > C | TT | 17 | 14 | 7 | 0.094 | |
| TC | 25 | 7 | 10 | |||
| CC | 1 | 3 | 3 | |||
| CYP2B6 | c.1459 C > T p.R487C | CC | 34 | 20 | 17 | 0.824 |
| CT | 9 | 4 | 3 | |||
| TT | 0 | 0 | 0 | |||
| c.62 A > T p.Q21L | AA | 43 | 24 | 19 | 0.183 | |
| AT | 0 | 0 | 1 | |||
| TT | 0 | 0 | 0 | |||
| c.1172 T > A p.I391N | TT | 43 | 24 | 19 | 0.183 | |
| TA | 0 | 0 | 1 | |||
| AA | 0 | 0 | 0 | |||
| c.136 A > G p.M46V | AA | 42 | 24 | 20 | 0.595 | |
| AG | 1 | 0 | 0 | |||
| GG | 0 | 0 | 0 | |||
| c.1061 A > G p.Y354C | AA | 42 | 21 | 19 | 0.226 | |
| AG | 1 | 3 | 1 | |||
| GG | 0 | 0 | 0 | |||
| c.64 C > T p.R22C | CC | 38 | 21 | 14 | 0.154 | |
| CT | 5 | 3 | 6 | |||
| TT | 0 | 0 | 0 | |||
| c.1078 T > G p.S360A | TT | 43 | 24 | 19 | 0.183 | |
| TG | 0 | 0 | 1 | |||
| GG | 0 | 0 | 0 | |||
| c.777 C > A p.S259R | CC | 43 | 23 | 20 | 0.265 | |
| CA | 0 | 1 | 0 | |||
| AA | 0 | 0 | 0 | |||
| c.419 G > A p.R140Q | GG | 41 | 23 | 19 | 0.991 | |
| GA | 2 | 1 | 1 | |||
| AA | 0 | 0 | 0 | |||
| c.547 G > A p.V183I | GG | 41 | 24 | 20 | 0.350 | |
| GA | 2 | 0 | 0 | |||
| AA | 0 | 0 | 0 | |||
| c.1021 C > G p.H341D | CC | 39 | 24 | 19 | 0.288 | |
| CG | 4 | 0 | 1 | |||
| GG | 0 | 0 | 0 | |||
| c.1016 A > C p.E339A | AA | 40 | 24 | 19 | 0.423 | |
| AC | 3 | 0 | 1 | |||
| CC | 0 | 0 | 0 | |||
| c.1190 A > G p.H397R | AA | 42 | 24 | 20 | 0.595 | |
| AG | 1 | 0 | 0 | |||
| GG | 0 | 0 | 0 | |||
| c.516 G > T p.Q172H | GG | 28 | 14 | 16 | 0.140 | |
| GT | 15 | 7 | 4 | |||
| TT | 0 | 3 | 0 | |||
| c.785 A > G p.K262R | AA | 27 | 17 | 16 | 0.328 | |
| AG | 14 | 4 | 3 | |||
| GG | 2 | 3 | 1 | |||
| c.485–18 C > T | CC | 17 | 10 | 6 | 0.910 | |
| CT | 21 | 11 | 12 | |||
| TT | 5 | 3 | 2 | |||
| −82T > C | TT | 41 | 23 | 19 | 0.991 | |
| TC | 2 | 1 | 1 | |||
| CC | 0 | 0 | 0 | |||
| ALB | c.1226 A > G p.Q409R | AA | 43 | 24 | 19 | 0.183 |
| AG | 0 | 0 | 1 | |||
| GG | 0 | 0 | 0 | |||
| ABCB1 | c.1199 C > T p.S400N | CC | 40 | 21 | 17 | 0.573 |
| CT | 3 | 3 | 3 | |||
| TT | 0 | 0 | 0 | |||
| c.2677 T > G p.S893A | TT | 25 | 18 | 10 | 0.010 | |
| TG | 14 | 1 | 6 | |||
| GG | 4 | 5 | 4 | |||
| c.2687 T > C p.I896T | TT | 43 | 23 | 20 | 0.265 | |
| TC | 0 | 1 | 0 | |||
| CC | 0 | 0 | 0 | |||
| c.2602 A > G p.I868V | AA | 42 | 24 | 20 | 0.595 | |
| AG | 1 | 0 | 0 | |||
| GG | 0 | 0 | 0 | |||
| c.61 T > C p.N21D | TT | 38 | 22 | 19 | 0.398 | |
| TC | 5 | 1 | 1 | |||
| CC | 0 | 1 | 0 | |||
| c.3320 T > G p.Q1107P | TT | 43 | 23 | 20 | 0.265 | |
| TG | 0 | 1 | 0 | |||
| GG | 0 | 0 | 0 | |||
| c.3435 C > T p.I1145= | CC | 16 | 8 | 7 | 0.400 | |
| CT | 20 | 8 | 6 | |||
| TT | 7 | 8 | 7 | |||
| c.1236 A > G p.G412= | AA | 14 | 9 | 7 | 0.907 | |
| AG | 19 | 8 | 7 | |||
| GG | 10 | 7 | 6 | |||
| NQO1 | c.559 C > T p.P187S | CC | 30 | 13 | 13 | 0.789 |
| CT | 11 | 9 | 6 | |||
| TT | 2 | 2 | 1 | |||
| c.415 C > T p.R139W | CC | 40 | 22 | 17 | 0.582 | |
| CT | 3 | 2 | 3 | |||
| TT | 0 | 0 | 0 | |||
| −1128T > G | TT | 30 | 15 | 13 | 0.974 | |
| TG | 11 | 8 | 6 | |||
| GG | 2 | 1 | 1 | |||
| UGT1A9 | c.98 T > C p.M33T | TT | 41 | 24 | 18 | 0.288 |
| TC | 2 | 0 | 2 | |||
| CC | 0 | 0 | 0 | |||
| SULT1A1 | c.638 G > A p.R213H | GG | 21 | 10 | 13 | 0.465 |
| GA | 19 | 13 | 7 | |||
| AA | 3 | 1 | 0 |