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. 2017 Nov 13;7:15383. doi: 10.1038/s41598-017-15557-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conservation of the Notch pathway in glass sponges. (a.) Schematic representation of the Notch pathway. In blue the components retrieved in glass sponges, in green the component retrieved in glass sponges but not described in other poriferan lineages until now and in black the element absent in glass sponges and other poriferan. The three successive cleavages of Notch are indicated: S1, S2 and S3. (b.) Domain composition of Notch and Delta proteins. (c.) Alignment of the Delta/Jag cysteine motif. (d.) Domain composition of Furin and ADAM proteins. (e.) Phylogenetic analysis revealing two ADAM10/17 in glass sponges. Black and white triangles represent clades of proteins with a node support higher than 95% and lower than 70%, respectively. (f.) Conservation of the proximal domain of ADAM as shown by the conservation of the cysteine motif. (g.) Domain composition of SuH and CoR1.