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. 2017 Nov 13;7:15453. doi: 10.1038/s41598-017-14894-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Paladin has a broad expression in the postnatal lung. (a) Endothelial cells and pneumocytes type II were isolated from lungs of mT/mG mice expressing endothelial-specific Tie2-Cre (left) or pneumocyte type II-specific SPC-Cre (right). Q-PCR of sorted single cells indicates Pald1 mRNA expression in both endothelial cells and non-endothelial cells, including pneumocytes type II, both at 3 weeks and 3 months of age. Expression was normalized to 18 S RNA. (b) Pald1 LacZ reporter activity (blue) is detected in Pald1 ^LacZ/LacZ mice, 5 days, 4 weeks and 19 weeks after birth. LacZ is broadly expressed in the lung tissue, except for the bronchial epithelium, which shows no reporter activity (arrow). Scale bar = 200 µm.