Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 13;7:15453. doi: 10.1038/s41598-017-14894-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Increased apoptosis and proliferation of endothelial cells in Pald1 knock-out female lungs. (a,b) Quantification of cleaved caspase-3 positive (CC3+) cells in 4 and 19-week old lungs revealed a significant increase in the number of cleaved caspase-3 positive endothelial cells (Erg positive) at 4 weeks of age and at 19 weeks in female (a, n = 3–4), but not in male Pald1 ^−/− mice (b, n = 3–4). There was no significant increase in non-endothelial cells (Erg negative) at both 4 and 19 weeks. (c,d) Quantification of Ki67 positive cells in 4 and 19-week old lungs revealed an increased number of Ki67-positive endothelial cells (Erg positive) in female (c, n = 3–4), but not in male Pald1 ^−/− mice (d, n = 3–4). There was no significant increase in non-endothelial cells (Erg negative) at both 4 and 19 weeks. Error bars: SD, t-test between genotypes within each age group. * = p ≤ 0.05, **** = p ≤ 0.0001.