. 2017 Nov 13;7:15453. doi: 10.1038/s41598-017-14894-9

Table 1.

Functional lung tests in 20-week old Pald1 ^+/+ and Pald1 ^−/− mice. Lung function was assessed by a forced maneuver system and a Fine-Pointe RC system. Differences between genotypes were evaluated by Wilcoxon test. Data are presented as median values ± interquartile range.

	Female			Male
	Pald1 ^+/+ (n = 6)	Pald1 ^−/− (n = 6)	p-value	Pald1 ^+/+ (n = 7)	Pald1 ^−/− (n = 5)	p-value
	Median	Median		Median	Median
	[25%; 75%]	[25%; 75%]		[25%; 75%]	[25%; 75%]
Body weight (g)	26.2	25.6	0.623	34.9	33.4	0.093
Body weight (g)	[24.4, 27.7]	[23.6, 27.4]		[34.1, 36.4]	[32.8, 33.0]
Tidal volume (ml)	0.21	0.22	0.056	0.19	0.20	0.374
Tidal volume (ml)	[0.21, 0.21]	[0.22, 0.22]		[0.18, 0.21]	[0.20, 0.20]
Inspiratory capacity (ml)	0.695	0.885	0.026	0.871	1.340	0.026
Inspiratory capacity (ml)	[0.650, 0.755]	[0.832, 0.982]		[0.650, 0.755]	[1.320, 1.253]
Expiratory Reverse Volume (ml)	0.26	0.29	0.323	0.24	0.26	0.425
Expiratory Reverse Volume (ml)	[0.25, 0.29]	[0.28, 0.30]		[0.21, 0.26]	[0.24, 0.28]
Vital Capacity (ml)	0.97	1.17	0.026	1.23	1.09	0.779
Vital Capacity (ml)	[0.90, 1.01]	[1.12, 1.29]		[0.90, 1.46]	[1.12, 1.29]
Functional Residual Capacity (ml)	0.295	0.310	0.370	0.325	0.295	0.980
Functional Residual Capacity (ml)	[0.290, 0.308]	[0.292, 0.328]		[0.329, 0.369]	[0.275, 0.365]
Residual Volume (ml)	0.025	0.035	0.649	0.029	0.056	0.649
Residual Volume (ml)	[0.020, 0.053]	[0.030, 0.040]		[0.025, 0.035]	[0.030, 0.040]
Total lung capacity (ml)	1.005	1.190	0.022	1.472	1.695	0.096
Total lung capacity (ml)	[0.962, 1.032]	[1.137, 1.302]		[1.362, 1.532]	[1.137, 1.859]
Forced Vital Capacity (ml)	0.895	1.065	0.026	1.099	1.160	0.323
Forced Vital Capacity (ml)	[0.828, 0.925]	[1.015, 1.175]		[0.828, 1.125]	[1.015, 1.175]
Forced Expiratory Volume in 100 ms (ml)	0.885	1.030	0.028	1.058	1.097	0.507
Forced Expiratory Volume in 100 ms (ml)	[0.802, 0.915]	[0.982, 1.145]		[0.976, 1.129]	[0.872, 1.201]
Peak Expiratory Flow (ml/sec)	30.1	30.7	0.141	33.6	31.7	0.092
Peak Expiratory Flow (ml/sec)	[30.1, 30.5]	[30.6, 30.9]		[33.1, 34.5]	[30.8, 32.7]
Static lung compliance (ml/cm H₂O)	0.050	0.070	0.039	0.056	0.053	0.384
Static lung compliance (ml/cm H₂O)	[0.050, 0.058]	[0.063, 0.070]		[0.051, 0.059]	[0.051, 0.055]
Dynamic lung compliance (ml/cm H₂O)	0.02	0.03	0.015	0.04	0.03	0.370
Dynamic lung compliance (ml/cm H₂O)	[0.02, 0.02]	[0.03, 0.03]		[0.03, 0.05]	[0.03, 0.03]
Resistance (cm H₂O/ml/sec)	1.40	1.27	0.013	0.98	1.11	0.652
Resistance (cm H₂O/ml/sec)	[1.35, 1.45]	[1.23, 1.31]		[0.96, 1.11]	[1.01, 1.31]