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. 2017 Nov 13;7:15434. doi: 10.1038/s41598-017-15656-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased oxygen consumption reduces P1 cardiomyocyte proliferative rates. (A) Cell viability (mean ± SEM) measured in P1 cardiomyocyte culture under control conditions and treated for 48 hours with 5 nM rotenone (n = 3 for both); t-test, NS. (B) Basal OCR (mean ± SEM) using a Seahorse Flux Analyzer in P1 cardiomyocyte cultures, control condition and treated with 5 nM rotenone for 48 hours (n = 3 for both); t-test, *p < 0.05 vs. control. (C) ATP-linked OCR (mean ± SEM) in P1 cardiomyocyte cultures, control condition and treated with 5 nM of rotenone for 48 hours (n = 3 for both); t-test, *p < 0.05 vs. control. (D) Cell cycle analysis (mean ± SEM) in P1 cardiomyocyte cultures under control conditions and treated for 48 hours with 5 nM rotenone (n = 3 for both); two-way ANOVA, *p < 0.05 vs. control. (E) Percentage of Ki67⁺ cardiomyocytes (mean ± SEM) in P1 cardiomyocyte cultures (n = 4 for both); t-test, *p < 0.05). (F) Bars indicate P1 cardiomyocyte and fibroblast proliferative rates (mean ± SEM) of after 24 hours in culture under control conditions (n = 7) or when treated with 5 nM rotenone (n = 6) for 48 hours; two-way ANOVA, *p < 0.05 vs. control.