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. 2017 Nov 13;7:15375. doi: 10.1038/s41598-017-15491-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quality of included studies according to QUADAS-2 guidelines. Risk of bias and applicability concerns of each included study. Proportion of studies with risk of bias; proportion of studies with regarding applicability. The risk bias mainly raised from patient selection due to inappropriate inclusion and exclusion, and determined as “high”. Another source of bias was indefinite report of blind method and interval between imaging and MVI pathological detection, and determined as “unclear”.