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. 2017 Nov 13;7:15443. doi: 10.1038/s41598-017-15749-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The expression of WBSCR22 affected Caco-2 cell sensitivity to oxaliplatin. (A) Western blot analysis of WBSCR22 in Caco-2 cells transfected by Wbscr22 or vector constructs, respectively. (B) Proliferation study of the Caco-2-Wbscr22 and Caco-2-vector cells upon oxaliplatin treatment at the indicated concentration. The results were representative of three independent experiments and the results were expressed as the mean ± SD. (C) Western blot of WBSCR22 in the shCon or shRNA1 treated Caco-2 cells transfected by either Myc-DDK-WBSCR22 or vector constructs, respectively. (D) Cell proliferation of Caco-2 shRNA1-vector, shRNA1-Wbscr22, shCon-vector and shCon-Wbscr22 cells upon oxaliplatin treatment. The IC₅₀ value of each cell line was indicated. The results were representative of three independent experiments and the results were expressed as the mean ± SD.