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. 2017 Nov 13;8:1463. doi: 10.1038/s41467-017-01688-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Development of a genetic p53 sensor. a Relative luciferase expression is shown for three p53-repressed elements (RE) derived from CDC25C, SCD, and RGS13 promoters. b Relative luciferase expression is shown for four different fragments (F) derived from SCD promoter and/or 5′UTR/intron1. c Relative luciferase expression is shown for four p53-activated elements (AE) derived from p21 and PUMA promoters. d Combination of repressed and activated elements. Relative luciferase expression is given for cotransfection of indicated constructs. a, b, c, d The activation/repression folds were calculated between pCMV and pCMV-p53wt cotransfections and are given as numbers above the bars. All error bars represent the standard deviation (SD) of three independent experiments and Student’s two-tailed t-test values are represented comparing expression between pCMV and pCMV-p53wt cotransfections (***P < 0.001, **P < 0.01, *P < 0.05; ns, not significant; SRE, sterol regulatory element; CGIs, CpG islands)