Table 2.
Biochemical characteristics of rats according to different groups. Data are reported as mean±SD of eight rats carried out in duplicate
| Groups | Control | HFD | Lipitor | L-saponin | M-saponin | H-saponin |
|---|---|---|---|---|---|---|
| Liver index | 2.03%±0.06%* | 2.18%±0.13% | 2.06%±0.18%* | 2.07%±0.09% | 2.07%±0.09% | 2.06%±0.07%* |
| Final weight (g) | 450±43** | 576±37 | 532±77 | 568±65 | 579±56 | 581±68 |
| Gained weight (g) | 77±19* | 113±28 | 93±45 | 123±32 | 128±25 | 127±58 |
| TC (mmol/L) | 1.449±0.071** | 1.831±0.176 | 1.364±0.180** | 1.506±0.150** | 1.499±0.299** | 1.528±0.171** |
| TG (mmol/L) | 0.455±0.040** | 0.755±0.240 | 0.576±0.192** | 0.616±0.063** | 0.573±0.155** | 0.581±0.090** |
| LDL (mmol/L) | 0.150±0.022** | 0.288±0.055 | 0.186±0.039** | 0.249±0.047 | 0.254±0.058 | 0.213±0.047** |
| HDL (mmol/L) | 1.430±0.126** | 0.934±0.300 | 1.159±0.103* | 1.009±0.178 | 1.195±0.274** | 1.186±0.108** |
| ALT (U/L) | 35.525±4.362** | 73.850±28.292 | 46.263±6.901** | 54.088±14.198** | 38.788±16.593** | 36.063±8.772** |
| AST (U/L) | 88.925±20.541 | 109.150±16.449 | 107.438±24.674 | 90.150±10.144 | 97.113±21.672 | 100.925±16.595 |
| MDA (nmol/L) | 1.600±0.289 | 2.500±0.367 | 2.266±1.004 | 2.414±0.512 | 2.460±0.301 | 2.400±1.065 |
| SOD (U/L) | 243.939±14.979* | 222.479±11.844 | 232.619±17.457 | 230.798±23.572 | 247.445±27.572** | 241.753±22.158* |
| GSH-PX (mmol/L) | 20.111±0.008 | 20.080±0.073 | 20.110±0.005 | 20.020±0.135 | 20.114±0.007 | 20.093±0.046 |
| HMG-COAR (U/L) | 19.219±0.335 | 19.007±0.501 | 18.854±0.445 | 18.306±0.261** | 17.628±0.540** | 17.698±0.826** |
| TC in feces (μmol/g) | 1.412±0.090* | 1.206±0.042 | 0.993±0.117* | 1.113±0.103 | 1.193±0.099 | 1.173±0.181 |
| TBA in feces (μmol/g) | 2.380±0.338** | 3.586±0.259 | 3.422±0.230 | 3.679±0.118 | 4.333±0.205** | 5.253±0.096** |
P values are obtained from the independent sample t-test between two groups (HFD group and another group).
*
P<0.05: Indicate significant difference from the HFD group;
**
P<0.01: Indicate extremely significant difference from the HFD group; ALT: Glutamic-pyruvic transaminase; AST: Aspartate transaminase; GSH-PX: Glutathione peroxidase; HFD: High-fat-diet; HMG-CoAR: 3-hydroxy-3-methyl glutaryl coenzyme A reductase; MDA: Malondialdehyde; TBA: Total bile acid; TC: Total cholesterol; TG: Triglyceride