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. 2017 Nov 13;7:15441. doi: 10.1038/s41598-017-14843-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR-23b cluster and miR-125a-5p modulate ERKs/AKT signaling. (a) Western blots showing the effect of miR-23b, miR-24, miR-27b and miR-125a-5p enforced expression on ERKs or AKT activation. (b) AKT2 and ERK2 silencing after miR-24 or miR-125a-5p overexpression. (c) Luciferase assay showing indirect regulation of AKT2 and ERK2 after miR-24 or miR125a-5p overexpression. (d) Effect of siRNA mediated knockdown of SOS1, IQGAP1, KRAS and RAF-1 on ERKs and AKT pathways in A549 cells. Uncropped western blots are available in the Supplementary information.