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. 2017 Nov 13;7:15441. doi: 10.1038/s41598-017-14843-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

MiR-23b cluster and miR-125a-5p induce drug sensitivity in NSCLC cell lines. (a,b) Enforced expression of miR-23b, miR-24, miR-27b and miR-125a-5p in A549 cells reduced cell proliferation after cisplatin treatment. (c,d) Enforced expression of miR-23b, miR-24, miR-27b and miR-125a-5p in A549 and H1299 cells decreased cell proliferation after cisplatin or TRAIL treatment. (e) Overexpression of miR-23b, miR-24 and miR-27b increased apoptosis after cisplatin treatment in A549 cells, whereas miR-125a-5p had no effect. (f) Cells stably expressing miR-23b cluster are more sensitive to cisplatin compared to control cells, as assessed by Annexin V. Error bars indicate mean ± SD (n = 3). *p < 0.05, **p < 0.01 by two-tailed Student’s t test.