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. 2017 Nov 13;7:15441. doi: 10.1038/s41598-017-14843-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of miR-23b cluster and miR-125a-5p on lung tumorigenesis in vivo. (a) Box plots showing relative expression of mature miR-24, miR-27b and miR-125a-5p expression in 24 normal lung or 24 lung tumour tissues. (b,c) Scatter plots showing inverse correlation between miRNA and respective target gene in 323 (GRB2/miR-27b and miR-24-1/RALA) or 513 (miR-27b/KRAS and miR-24-1/IQGAP1) patients with NSCLC from the Cancer Genome Atlas (TCGA) data set LUAD (lung adenocarcinoma). (d) Representative images of CDX sections showing strong expression of PDGFR-β in cancer cells (Original magnifications: left panel 2x, right panel 8x of left panel insert; scale bars 250 µm). (e) Tumour volume of cohorts of CDX mice treated with a control miR (Ctr), miR-125a-5p or miR-27b/24. (f) Representative images of Ki67 expression in CDX tumors treated with control miR versus miR-125a-5p or miR-27b/24. (Original magnifications: 20x; scale bar 100 µm). Average Ki67 evaluation in the three groups (Ctr vs miR-125a: p < 0.001; Ctr vs miR-27b/24: p < 0.001). Error bars indicate mean ± SD and p values were calculated by two-tailed Student t test (*p < 0.05, **p < 0.001). r = Pearson correlation coefficient.