Table 1.

Sequences of various complex probes used in the study

Probe	Sequence
T2a	5ʹ-(CAT)10-gcugaccagcuaugaggucauacaucgucauagcac-(CAT)10-biotin-3ʹ
T2-PolyUb	5ʹ-(CAT)10-gcugaccagcuaugaggucauuuuuuuucauagcac-(CAT)10-biotin-3ʹ
Ref-HPc	5ʹ-(CAT)10-gcugaccucauagcuuuuuuugcuaugagguca-(CAT)10-biotin-3ʹ

^aT2 RNA forms a pseudoknot as shown in Fig. 1a

^bT2-PolyU RNA is the same as T2 RNA except that loop L2 (uacaucg) is substituted with a 7-nt polyU fragment (Fig. 5a)

^cReference hairpin forms a 12-bp joint helix of H1 and H2, and a 7-nt polyU loop (Supplementary Fig. 2a)