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. 2017 Nov 13;7:15377. doi: 10.1038/s41598-017-15807-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LMWH/tPA- and DNase1-treatment ameliorate tissue damage, apoptosis, and oxidative stress after midgut volvolus. (A) Chiu Score to assess intestinal damage. (B) HE staining: treatment with DNase1 or LMWH/tPA showed a significant improvement of gut viability after iatrogenic volvulus compared to controls. (C) Quantification of apoptotic cells per cross section detected by TUNEL. (D) Detection of apoptotic cells in tissue by staining for cleaved caspase 3 (brown). (E,F) MDA (oxidative stress) and GPx (antioxidative capacity) levels in tissue extracts. Treatment with either LMWH/tPA or DNase1 reduced oxidative stress relative to control animals, as demonstrated by a significant increase in MDA activity and a decrease in GPx activity in the controls as compared to treated animals. Data shown as Mean ± SD. Statistics: Kruskal-Wallis test, ANOVA.