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. 2017 Nov 13;7:15377. doi: 10.1038/s41598-017-15807-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LMWH/tPA, but not DNase1, interferes with hemostasis. (A) Experimental design. Rats were subjected to 360° volvulus for <1 min (Sham; N = 2) or 3 hours. Rats received inactivated DNase1 (Control; N = 4), active DNase1 (DNase1, N = 4), or a combination of LMWH and tPA (LMWH/tPA, N = 4) immediately after detorsion of the intestine. One hour after detorsion, blood hemostasis was determined by a tail-bleeding assay. (B) Tail bleeding time. (C) Loss of blood volume. LMWH/tPA, but DNase1, significantly increased the bleeding time and volume. Data shown as Mean ± SD. Statistics: ANOVA.