Table 2.
Potential upstream regulators or mediators of miR-7 predicted by target gene analysis.
| Upstream regulator | Molecular type | Predicted activation state a | Activation z-score | P-value of overlap |
|---|---|---|---|---|
| HGF | growth factor | Activated | 4.953 | 2.25E-16 |
| RABL6 | other | Activated | 4.796 | 4.91E-25 |
| CSF2 | cytokine | Activated | 4.7 | 9.42E-16 |
| PTGER2 | g-protein coupled receptor | Activated | 4.459 | 1.52E-28 |
| Vegf | group | Activated | 4.31 | 1.96E-14 |
| RARA | ligand-dependent nuclear receptor | Activated | 4.123 | 5.77E-08 |
| ESR1 | ligand-dependent nuclear receptor | Activated | 3.963 | 8.66E-10 |
| FOXM1 | transcription regulator | Activated | 3.696 | 4.82E-19 |
| E2f | group | Activated | 3.687 | 1.86E-16 |
| MITF | transcription regulator | Activated | 3.483 | 4.47E-13 |
| BNIP3L | other | Inhibited | −3.317 | 8.12E-10 |
| CDKN1A | kinase | Inhibited | −3.519 | 2.07E-33 |
| Irgm1 | other | Inhibited | −3.592 | 1.24E-14 |
| KDM5B | transcription regulator | Inhibited | −3.601 | 3.74E-08 |
| let-7 | microrna | Inhibited | −3.734 | 4.12E-15 |
| CDKN2A | transcription regulator | Inhibited | −3.764 | 3.21E-11 |
| phorbol myristate acetate | chemical drug | Inhibited | −4.448 | 2.89E-07 |
| TP53 | transcription regulator | Inhibited | −4.529 | 5.91E-26 |
| NUPR1 | transcription regulator | Inhibited | −5.488 | 6.02E-13 |
| calcitriol | chemical drug | Inhibited | −5.68 | 1.86E-25 |
aThe status of the regulator that results in the same expression profile of the target genes of miR-7 in the miR-7-overexpressing MCF-10A.