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. 2017 Nov 10;11(1):11–17. doi: 10.1016/j.tranon.2017.10.009

Figure 3.

Figure 3

Erythropoietin-producing hepatocellular carcinoma A2 (EphA2)-specific T cells recognize and kill EphA2-positive lung cancer cells. (A) Non-transduced (NT) or EphA2-specific T cells were cocultured with target cells at 5:1, 1:1 and 1:5 ratio, and after 24 hours, percentage of IFN-γ-expressing T cells was determined by FCM. A higher percentage of IFN-γ-expressing T cells was occurred in comparison to the EphA2-negative T cells and K562. (B) EphA2-specific T cells showed a significant lower CI against A549 whereas non-transduced T cells, and a rapid and precipitous increase in CI occurred in the control group (only A549). And the stronger cytotoxic activity against A549 was observed at the higher effector to target (E: T) ratio of 20:1.