Figure 10.

Schematic Diagram Showing the Mechanism of How miR-3174 Upregulation in GC Cells Contributes to Apoptosis and ACD Deficiency

miR-3174 expression is upregulated in GC cells and leads to cell death defects by directly targeting ARHGAP10, which could not only promote mitochondria-dependent apoptosis by enhancing p53 expression, followed by Bax trans-activation and caspase cleavage, but also facilitate autophagic cell death by suppressing mammalian target of rapamycin complex 1 (mTOC1) activity.