Fig. 2.

Source-based morphometry results showing the eight patterns of gray matter (GM) volume that were identified in all 152 multiple sclerosis patients and 31 healthy controls at baseline. Z-scores, thresholded at | 3 |, are shown in red-yellow for each component, with yellow being associated with larger values. Compared to healthy controls, multiple sclerosis patients had significantly reduced GM volume in Patterns 1 and 7 after correction for multiple comparisons. The X, Y and Z values refer to the slice shown in Montreal Neurological Institute coordinates.