Table 2.
MRI volumetry of multiple sclerosis patients at baseline and changes over follow-up.
| Without CDP group (n = 67) | With CDP group (n = 85) | HC group (n = 31) | Without CDP vs. CDP p-value | MS patients vs. HC p-value | |
|---|---|---|---|---|---|
| Baseline T2 lesion volume, mean (SD) | 6.1 (9.9) | 9.1 (10.5) | – | 0.080 | – |
| Baseline whole brain volume, mean (SD) | 1515.8 (76.3) | 1502.4 (81.1) | 1592.0 (87.5) | 0.305 | < 0.0001 |
| Baseline gray matter volume, mean (SD) | 813.2 (48.7) | 805.2 (54.1) | 847.1 (50.9) | 0.349 | < 0.0001 |
| T2 lesion volume absolute change, mean (SD) | 2.9 (5.5) | 4.2 (7.5) | – | 0.273 | – |
| Percent brain volume change, mean (SD) | − 5.3 (3.0) | − 7.5 (3.8) | – | < 0.0001 | – |
| Percent gray matter volume change, mean (SD) | − 5.8 (2.8) | − 7.1 (3.7) | – | 0.007 | – |
Legend: CDP – confirmed disability progression.
Baseline p-values were calculated using Student's t test while changes over follow-up were derived using analysis of covariance, correcting for age and sex. Volumes are presented in mL.