. 2017 Oct 31;2017:3539872. doi: 10.1155/2017/3539872

Table 2.

Univariate Cox proportional regression of ICU delirium in sequential sedation patients.

Variables	RR	95% CL	p
Age (≥51)	1.957	1.112–3.444	0.020^※※
Allergic history	2.013	0.626–6.467	0.240
Regular drinking	1.078	0.613–1.895	0.795
Regular smoking	1.580	0.908–2.750	0.106^※
Hypertension	1.249	0.642–2.430	0.513
APACHE II (≥23)^a	1.146	0.621–2.115	0.663
SOFA score (≥14)^a	1.801	1.016–3.190	0.044^※※
The first dose of midazolam (mg/kg/d)^a	1.095	0.833–1.438	0.515
The first dose of fentanyl (μg/kg/d)^a	1.040	1.004–1.077	0.030^※※
The maintenance dose of midazolam (mg/kg/d)^b	1.048	1.001–1.097	0.043^※※
The maintenance dose of fentanyl (μg/kg/d)^b	1.025	1.004–1.047	0.021^※※
The accumulated dose of midazolam (mg)^b	1.000	0.999–1.001	0.960
The accumulated dose of fentanyl (mg)^b	0.968	0.916–1.023	0.252
Time of patients meeting sequential criteria to stop sedation^c	1.003	0.995–1.011	0.486
Time of patients meeting sequential criteria for extubation^c	1.002	0.995–1.009	0.635
Sequential sedatives^c
Midazolam (group M-M)	1.000	Ref.
Propofol (group M-P)	0.863	0.456–1.634	0.652
Dexmedetomidine (group M-D)	0.451	0.217–0.939	0.033^※※

^aPatients at ICU admission (before meeting the sequential criteria). ^bWhen patients met the sequential criteria. ^cAfter patients met the sequential criteria for extubation. ^※p < 0.2, ^※※p < 0.05.