Table 3.
Multivariate Cox proportional regression of ICU delirium in sequential sedation patients.
| Risk factors | RR | 95% CL | p |
|---|---|---|---|
| Age (≥51) | 2.432 | 1.316–4.494 | 0.005※※ |
| Regular smoking | 2.366 | 1.277–4.382 | 0.006※※ |
| SOFA score (≥14)a | 2.022 | 1.076–3.798 | 0.029※※ |
| The first dose of fentanyl (μg/kg/d)a | 0.992 | 0.951–1.035 | 0.772 |
| The maintenance dose of midazolam (mg/kg/d)b | 1.052 | 1.000–1.107 | 0.049※※ |
| The maintenance dose of fentanyl (μg/kg/d)b | 1.045 | 1.019–1.072 | 0.001※※ |
| Sequential sedativesc | |||
| Midazolam (group M-M) | 1.000 | Ref. | |
| Propofol (group M-P) | 0.706 | 0.364–1.369 | 0.303 |
| Dexmedetomidine (group M-D) | 0.448 | 0.209–0.963 | 0.040※※ |
aPatients at ICU admission (before meeting the sequential criteria). bWhen patients met the sequential criteria. cAfter patients met the sequential criteria for extubation. ※※p < 0.05.