Table 2.
Effects of tamoxifen, 17β-estradiol, and genistein on crossing, grooming, and rearing in the locomotor activity test.
| Groups | Crossing (n) | Grooming (s) | Rearing (s) |
|---|---|---|---|
| Vehicle | 44.1 ± 1.7 | 10.3 ± 0.9 | 23.7 ± 2.0 |
| T | 52.5 ± 4.2 | 9.2 ± 1.1 | 21.5 ± 2.0 |
| 17β-E2 | 41.5 ± 2.4 | 22.6 ± 2.0∗ | 30.8 ± 2.3∗ |
| 17β-E2-T | 47.2 ± 3.0 | 7.1 ± 0.8 | 18.3 ± 0.9 |
| Genistein | 41.7 ± 2.4 | 18.4 ± 2.2∗ | 33.0 ± 3.0∗ |
| Genistein-T | 50.1 ± 3.8 | 8.8 ± 0.8 | 17.7 ± 1.8 |
∗ p < 0.05, versus Vehicle, T, 17β-E2-T, and Genistein-T. One-way ANOVA followed by Student-Newman-Keuls post hoc test. T, 5 mg/kg tamoxifen; 17β-E2, 0.09 mg/kg 17β-estradiol; Genistein 0.09 mg/kg.