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. 2017 Nov 14;5:17022. doi: 10.1038/boneres.2017.22

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Copyright © 2017 The Author(s)

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sCSF1 K/O mice are protected against estrogen-deficiency bone loss. (a) Mean BMD values determined by DXA in Wt mice (upper panel) and K/O mice (bottom panel) following sham-OVX or OVX. (b) Femoral trabecular BV/TV assessed by micro-CT. (c) 3D reconstructions of micro-CT images of diaphyseal bone in Wt-OVX and K/O-OVX. Note the greater amount of trabecular bone in the K/O-OVX animals. Results are expressed as M±s.e.m. and analyzed by two-way ANOVA for the data in a and by Mann–Whitney for the data in b. ANOVA, analysis of variance; BMD, bone mineral density; K/O, knockout; M, mean; NS, not significant; OVX, ovariectomy, ***P<0.000 1, **P=0.02.