Table 1.
List of all parameters used in numerical simulations.
| Parameter | Interpretation (units) |
Estimated value | Reference |
|---|---|---|---|
| r | Tumor growth rate t−1 = day−1 |
0.0033 | Shochat et al., 1999 |
| α 1 | Rate of elimination of cancer cells by effector cells cell day−1 |
1.1 × 10−7 | Kuznetsov et al., 1994 |
| k | Inhibitory parameter | 2 × 103 | Not found |
| a 1 | Recruitment rate of effector cells t−1 = day−1 |
0.25 | Sud D. et al., 2006 |
| a 2 | Activation rate of effector cells by the BCG cells−1 day−1 |
0.052 | Wigginton and Kirschner, 2001 |
| δ | Internal production of immune checkpoints | 1.51932 × 105 | Sandip Banerjee et al., 2015 |
| α 2 | Elimination rate of effector cells by cancer cells cells−1 day−1 |
3.45 × 10−10 | Kuznetsov et al., 1994 |
| μ 1 | Degradation rate of effector cells t−1 = day−1 |
0.041 | Kuznetsov et al., 1994 |
| μ 2 | Rate of BCG decay t−1 = day−1 |
0.1 | Archuleta et al., 2002 |
| b | Bioeffective concentration of BCG c.f.u./day |
6.5 × 105 | Cheng et al., 2004 |
| α 3 | Destruction of BCG by effector cells cells−1 day−1 |
1.25 × 10−7 | Wigginton and Kirschner, 2001 |
| μ 3 | Degradation rate of immune checkpoints t−1 = day−1 |
166.32 | Sandip Banerjee et al., 2015 |