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. 2017 Nov 9;10:357. doi: 10.3389/fnmol.2017.00357

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Copyright © 2017 Ganai, Abdullah, Rashid and Altaf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

E-Pharmacophoric features of LAQ824 and HC-toxin against HDAC1 and HDAC2 enzymes. LAQ824 shows distinct features against HDAC1 and HDAC2. For HDAC1, LAQ824 portrays five features while for HDAC2 it shows only three features. Two extra features both in linker region of LAQ824 (P8 and D4) were seen for LAQ824 while in the binding pocket of HDAC1 as compared to HDAC2. While HC-toxin portrayed three features (hydrophobic group in linker region, HBA in ZBG and HBD in cap region) against HDAC1, only one feature (HBA in ZBG) was seen against HDAC2. (A) HDAC1- LAQ824, (B) HDAC2- LAQ824, (C) HDAC1- HC-toxin, and (D) HDAC2- HC-toxin.