Table 2.
Comparative dissolution profile of nine batches of SD prepared using polymer P1 (Soluplus) and P2 (Kolliphor TPGS) in acetate buffer pH 4.5. Data presented as mean ± SD, n = 3 for each formulation.
| Formulation code | Polymer | Cumulative % drug release (±SD) (n = 3) | ||
|---|---|---|---|---|
| After 30 min | After 60 min | After 90 min | ||
| SD1 | P1 | 25.9 ± 0.541 | 37.4 ± 1.003 | 38.6 ± 0.536 |
| SD2 | P1 | 28.6 ± 0.312 | 48.7 ± 0.978 | 56.3 ± 0.612 |
| SD3 | P2 | 27.8 ± 1.012 | 48.9 ± 0.346 | 58.5 ± 0.830 |
| SD4 | P2 | 25.3 ± 0.664 | 34.6 ± 0.843 | 41.1 ± 0.964 |
| SD5 | P1 | 15.5 ± 0.718 | 30.3 ± 0.516 | 42.8 ± 0.521 |
| SD6 | P2 | 41.8 ± 0.992 | 61.9 ± 0.982 | 68.6 ± 0.843 |
| SD7 | P2 | 61.2 ± 0.813 | 98.5 ± 0.945 | 98.8 ± 1.262 |
| SD8 | P1 | 28.5 ± 1.408 | 42.2 ± 0.397 | 43.6 ± 0.325 |
| SD9 | P1 | 25.1 ± 0.119 | 34.0 ± 0.863 | 39.1 ± 1.463 |
| SD10 | P2 | 30.1 ± 0.761 | 63.4 ± 0.214 | 71.4 ± 1.332 |
| SD11 | P2 | 35.4 ± 0.218 | 54.9 ± 0.343 | 63.6 ± 0.525 |
| SD12 | P1 | 28.7 ± 0.558 | 39.8 ± 0.436 | 41.7 ± 0.358 |
| SD13 | P2 | 38.8 ± 0.592 | 70.8 ± 0.951 | 85.5 ± 1.175 |
| SD14 | P1 | 12.6 ± 1.117 | 23.5 ± 1.265 | 37.3 ± 0.453 |
| SD15 | P2 | 32.5 ± 0.476 | 52.8 ± 1.478 | 63.3 ± 0.543 |
| SD16 | P2 | 40.1 ± 0.845 | 55.8 ± 0.659 | 64.6 ± 0.866 |
| SD17 | P1 | 26.0 ± 0.327 | 44.4 ± 1.367 | 55.5 ± 0.634 |
| SD18 | P1 | 19.2 ± 0.574 | 34.0 ± 0.512 | 39.1 ± 0.652 |
P1 = Soluplus; P2 = Kolliphor TPGS.