FIG. 3.

IL-21-IgFc supports both CD4⁺ and CD8⁺ T cell effector function. (A) Longitudinal representation of the frequency of effector memory CD4⁺ T cells (left) and areas under the curve for effector memory CD4⁺ T cells in control and IL-21-IgFc–treated animals (right). (B) Longitudinal representation of the frequency of effector memory CD8⁺ T cells (left) and areas under the curve for effector memory CD8⁺ T cells (right). (C, D) Longitudinal representation of the frequency of IFN-γ–producing T cells among total CD4⁺ and CD8⁺ subsets. (E) Longitudinal frequency of IFN-γ–producing, SIV-specific CD8⁺ T cells (left) and area under the curve for such cells (right). (F) Longitudinal representation of IFN-γ- and TNF-α–producing, SIV-specific CD8⁺ T cells (left) and area under the curve for such cells (right). (G) Inverse trend between IFN-γ–producing, SIV-specific CD8⁺ T cells and plasma viral loads at 2 weeks postinfection. SIV, simian immunodeficiency virus; TNF-α, tumor necrosis factor alpha.