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. 2017 Nov 1;33(Suppl 1):S-70–S-80. doi: 10.1089/aid.2017.0159

FIG. 2.

FIG. 2.

Creation of a CCR5xCD3 bispecific antibody. (A) Overlay of HIC peaks for parental antibodies, loaded alone or as a mixture, and for bispecific product following controlled Fab arm exchange. (B) cIEF results for parental antibodies and bispecific product. (C) Plot of HIC retention times versus pI calculated from cIEF (highest peak), confirming that bispecific product had expected characteristics relative to the parental antibodies. cIEF, capillary isoelectric focusing; HIC, hydrophobic interaction chromatography; pI, isoelectric points.