Figure 1.

Survival rate during the repeated dosing of LCZ696 and valsartan for 12 weeks. Initial number of animals in each group: n = 8 in the sham, n = 18 in the vehicle, n = 9 in the valsartan‐(5 mg/kg), n = 13 in the valsartan‐(10 mg/kg), n = 6 in the LCZ696‐(10 mg/kg) and n = 10 in the LCZ696‐(30 mg/kg) Mean survival period in rats with vehicle was 100 days {8 weeks (56 days) after subtotal nephrectomy +34 days after dosing of vehicle}. *P < 0.05, **P < 0.01 versus vehicle; #P < 0.05 versus valsartan‐(15 mg/kg).