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Serum creatinine (A) and urinary protein excretion (B) during the repeated dosing of LCZ696 and valsartan for 12 weeks. All data obtained at each observation point were used. The number of rats of each point was described in Fig. 2. *P < 0.05, **P < 0.01 versus vehicle; #P < 0.05 versus valsartan‐(15 mg/kg); Mean ± SD.
