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(A) Serum ANP concentration, (B) urinary excretions of ANP, (C) cGMP, (D) nitric oxide, and (E) ET‐1 after the repeated dosing of valsartan‐(15 mg/kg) and LCZ696‐(30 mg/kg) for 8 weeks. Data were obtained in rats survived at 8 weeks. Number of animals; n = 4 in the vehicle and valsartan‐(15 mg/kg) groups, and n = 5 in the LCZ696‐(30 mg/kg) and sham groups. STNx; subtotal nephrectomy, *P < 0.05, **P < 0.01; Mean ± SD.
