Table 1.
Physiological, morphological, and cardiac functional parameters of DS/lean and DS/obese rats treated or not with everolimus at 13 weeks of age
| Parameter | CONT | Cont + Eve | MetS | MetS + Eve |
|---|---|---|---|---|
| Heart weight/tibial length (mg/mm) | 32.19 ± 0.67 | 33.78 ± 0.76 | 42.87 ± 0.60a, b | 34.12 ± 0.39a, c |
| LV weight/tibial length (mg/mm) | 24.16 ± 0.65 | 24.17 ± 0.65 | 32.43 ± 0.51a, b | 24.71 ± 0.40a, b, c |
| Liver weight/tibial length (mg/mm) | 283.30 ± 9.54 | 296.35 ± 14.18 | 612.89 ± 31.39a, b | 568.94 ± 19.50a, b |
| Pancreas weight/tibial length (mg/mm) | 42.20 ± 3.86 | 39.44 ± 1.95 | 28.68 ± 1.66a, b | 29.85 ± 1.97a, b |
| Kidney weight/tibial length (mg/mm) | 3029.67 ± 157.04 | 2920.40 ± 103.09 | 3350.88 ± 99.12a, b | 2522.00 ± 65.15a, b, c |
| Retroperitoneal fat weight/tibial length (mg/mm) | 111.71 ± 5.99 | 113.78 ± 2.71 | 399.11 ± 19.55a, b | 334.74 ± 9.21a, b, c |
| Epididymal fat weight/tibial length (mg/mm) | 122.27 ± 7.33 | 129.14 ± 3.46 | 317.03 ± 12.12a, b | 242.55 ± 10.15a, b, c |
| Inguinal fat weight/tibial length (mg/mm) | 195.63 ± 7.15 | 196.56 ± 8.21 | 1105.49 ± 59.28a, b | 765.81 ± 23.86a, b, c |
| IVSTd (mm) | 1.63 ± 0.05 | 1.76 ± 0.04 | 2.12 ± 0.10a, b | 1.63 ± 0.02a, b, c |
| LVDd (mm) | 8.09 ± 0.22 | 7.65 ± 0.12 | 7.58 ± 0.20 | 8.05 ± 0.07 |
| LVPWTd (mm) | 1.56 ± 0.09 | 1.70 ± 0.06 | 2.16 ± 0.09a, b | 1.68 ± 0.05c |
| LV mass (mg) | 948.71 ± 51.33 | 962.28 ± 30.76 | 1286.0 ± 64.26a, b | 986.71 ± 25.23 |
| RWT | 0.39 ± 0.02 | 0.45 ± 0.02 | 0.57 ± 0.04a, b | 0.41 ± 0.01c |
| FS (%) | 32.62 ± 1.67 | 35.33 ± 1.87 | 44.43 ± 1.71a, b | 38.55 ± 1.09a, b |
| EF (%) | 69.10 ± 2.22 | 72.20 ± 2.34 | 82.46 ± 1.65a, b | 76.47 ± 1.20a, b |
| E/A | 1.95 ± 0.09 | 1.72 ± 0.06 | 1.54 ± 0.13a | 1.91 ± 0.07c |
| DcT (ms) | 33.89 ± 1.40 | 38.2 ± 1.45 | 43.45 ± 1.23a, b | 35.82 ± 0.68c |
| IRT (ms) | 24.22 ± 2.42 | 31.43 ± 1.47 | 38.35 ± 1.84a, b | 34.39 ± 1.07c |
| Tau (ms) | 27.47 ± 0.82 | 29.01 ± 2.59 | 36.72 ± 1.45a, b | 28.77 ± 1.73c |
| LVEDP/LVDd (mmHg/mm) | 0.56 ± 0.04 | 0.60 ± 0.05 | 1.08 ± 0.11a, b | 0.65 ± 0.05c |
Values are expressed as means ± SEM for surviving animals (organ weight and echocardiography; n = 8, 10, 7, and 12, cardiac catheterization; n = 4, 5, 3, and 9 for DS/lean rats treated with vehicle (Cont), DS/lean rats treated with everolimus (Cont + Eve), DS/obese rats treated with vehicle (MetS), and DS/obese rats treated with everolimus (MetS+Eve), respectively).
a
P < 0.05 versus CONT.
b
P < 0.05 versus Cont + Eve.
c
P < 0.05 versus MetS.