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. Author manuscript; available in PMC: 2017 Nov 14.
Published in final edited form as: Nat Rev Drug Discov. 2016 Nov 25;16(2):101–114. doi: 10.1038/nrd.2016.211

Figure 2. Structures of compounds used for induced protein degradation technologies.

Figure 2

A) Hydrophobic tags (HyTs) utilized to recruit chaperones to a protein of interest (POI): adamantane and Arg-Boc3. B) E3 ligase recruiting ligands employed to hijack E3 ligases to ubiquitinate and degrade POIs. The wavy line illustrates the attachment point utilized in the studies discussed. C) The chemical structures of proteolysis-targeting chimeras (PROTACs) utilizing different E3 ligases to target the POIs for degradation. The POI ligands are shown in blue; the linkers are shown in black; and the E3 ligase recruiting ligands are shown in red.