Table 1. Effect of TMX in the estrous cycle of ovariectomized mice.

Experimental groups	Evaluation of the estrous cycle before treatments			Evaluation of the estrous cycle after treatments
SO	Met.	Met.	Met.	Met.	Met.	Diest.
E2 (50 µg/kg)	Diest.	Met.	Met.	Est.	Est.	Est.
TMX
0.3 mg/kg	Met.	Met.	Met.	Pro.	Pro.	Est.
0.9 mg/kg	Diest.	Met.	Met.	Est.	Est.	Est.
2.7 mg/kg	Met.	Met.	Met.	Est.	Est.	Est.

The experimental groups consisted in ovariectomized mice treated with 17β-estradiol (E2, 50 µg/kg, sc), different doses of tamoxifen (TMX, 0.3, 0.9, and 2.7 mg/kg, sc) or only with sesame oil (SO, vehicle, sc). The estrous cycle stage was evaluated before and after treatments and determined in pro-estro (Pro.), estrus (Est.), diestrous (Diest.), and metaestrous (Met.).