Table 3.

Pharmacokinetic parameter estimates from the final model with renal function treated as a categorical variable

PK parameter	Estimate	Bootstrap median estimate	90% bootstrap CIa
Ka (1/h)	0.724	0.774	0.533–1.23
V/F (L)	58.300	58.521	51.597–66.055
CL/Fnormal (L/h)	5.130	5.159	4.283–6.069
CL/F ratio (group 2 vs group 1)	1.020	1.019	0.848–1.195
CL/F ratio (group 3 vs group 1)	1.010	1.018	0.871–1.169
CL/F ratio (group 4 vs group 1)	0.724	0.729	0.606–0.844
Tlag (h)	0.154	0.183	0.002–0.43
ω2 (Ka)	0.782	0.804	0.441–1.387
ω2 (V/F)	0.139	0.136	0.069–0.236
ω (V/F):ω (CL/F)	0.163	0.156	0.088–0.236
ω2 (CL/F)	0.198	0.189	0.121–0.273
δ2	0.341	0.321	0.194–0.459

Notes: CL/F_normal, apparent clearance for patients with normal renal function; Ka, absorption rate constant; Tlag, lag time; V/F, apparent volume of distribution; ω², variance of interpatient variability; δ², variance of intra-patient variability. Group 1 represents patients with normal renal function; group 2 represents patients with moderately impaired renal function; group 3 represents patients with severely impaired renal function not requiring hemodialysis; and group 4 represents patients with severely impaired renal function requiring hemodialysis.

^aBootstrap CI values were taken from bootstrap calculation.

Abbreviation: PK, pharmacokinetics.